Qiyb2 is an abstract 2D score-attack auto-platformer with over 60 different random-generated cubes, hand-drawn backgrounds and experimental soundtracks. Precision in landing jumps, mastery over the skills and knowledge of the different effects and their synergies are key to attaining a high score.

In this game, the player controls an automatically jumping cube, with other cubes working as platforms, where by jumping on them activates their effect. The different cubes that can be generated form as a collection a so-called probability hierarchy, where the cube's rarity usually defines how powerful its effect on the game can be. Example effects include basic score gain, negation that changes the next effect of many cubes, temporary score gain multiplier increase, and a rare and temporary domain shift.

The game has a dynamic difficulty level that corresponds to how high the player's score is: the higher the score, the higher the difficulty, indicated by the difficulty meter in the lower right corner of the HUD (starting from 'Zero', all the way up to 'Champion'). The main objective is to obtain as high a score as possible, where certain score amounts introduce additional random events that can occur, such as an enemy or boss spawning, or a fast negative hit points cube wall approaching.

The player starts with one skill called height reset. There are four additional skills with corresponding skill paths that can be purchased from the shop with the game currencies obtained by playing the game. Teleportation, for example, can be used to teleport through a negative hit points cube wall, thus avoiding its effect, and time dilation can be used to temporarily slow time to grant the player more time to act to the given situation. Each skill has its own cooldown time. The game has over 80 unlockables in total, including skills, perks, skins, backgrounds and soundtracks.

There are over seven bosses in the game, with varying difficulty levels, and corresponding rewards when defeating them. There is no tutorial, as the emphasis is on experimentation, akin to mathematics, where one experiments to discover something new and learn the rules of the game.