S.E.M.I. – Side Effects May Include... - Player count and game stats

S.E.M.I. – Side Effects May Include... is tagged as Action, Indie. It is published by Two Horn Unicorn and released on 23 Jan, 2026. This page tracks live Steam player counts, historical peaks, and regional pricing. and the all-time peak was 89 concurrent players on 21 November 2025.

S.E.M.I. – Side Effects May Include... header image

Developer: Two Horn Unicorn

Publisher: Two Horn Unicorn

Platforms:

Release Date: 23 Jan, 2026

Official site On Steam Details

Est. sales: 2,670 High confidence

Top-selling rank: #1437 YTD

About S.E.M.I. – Side Effects May Include...

S.E.M.I. is a single-player and co-op action platformer with puzzle elements. Play as patients of an unusual clinic, take experimental drugs, interfere with each other, and be ready for chaos and unpredictable side effects!

More S.E.M.I. – Side Effects May Include... Details

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here, you and up to 3 of your brainless loyal friends play as patients, fighting staff and other patients while stumbling into all sorts of unexpected situations. Brawls, side-effect pills, and brutal platforming will absolutely challenge your clumsy friends’ hands sense of teamwork. Expect obstacles, puzzles, deadly traps, and rooms where a single wrong move can knock out the entire squad.

Communicate in voice chat and arrange sabotage help your friends pass through rooms, get out of traps and fight with opponents! In your arsenal: close combat, physics, amazing abilities and ... imagination!

Take pills and get abilities:

Bipolar force is an invulnerable monster, then a helpless rag!
Laser astigmatism — two sights, one laser… Where will he shoot?
Stendhal syndrome — are you looking at a painting? Now you're hysterical and destroying everything around you!
Alice's syndrome is either tiny or gigantic — have time to adjust!

Madness is near! You and your friends can go crazy and start running, jumping and fighting, and your abilities will become uncontrollable. Do you want to take back control? Take the pills :)

Locations are randomly generated from rooms with changing gravity, traps, moving walls, and other "pleasant" surprises.

After a successful escape, you will receive a medical report: "The patient was stable until he started hitting the guards with a bottle. Diagnosis: Overmotivation" or something worse!

Unlock new costumes and decorations. Let each new escape be more stylish than the previous one!

Will you and your friends be able to escape... or at least not go crazy?

Welcome to the mental hospital! Here, your abilities are a lottery, and your friends can be the most dangerous opponents!

Controller Support: full
Genres: Action, Indie
Categories: Single-player, Multi-player, Co-op, Online Co-op, Steam Achievements, Full controller support, Custom Volume Controls, Playable without Timed Input, Stereo Sound, Surround Sound, Family Sharing
Supported Languages: English, Russian, French, German, Spanish - Spain, Simplified Chinese, Portuguese - Brazil, Japanese, Korean
Last Checked: 2026-08-05T12:48:54.611Z

Peak Concurrent Players

Loading peak stats…

Hourly Daily Monthly Yearly

Daily Monthly Yearly

PC System Requirements

Price History

Your Selected Region: -

Player Reviews

Loading reviews…

Official Announcements

Loading official news…

News from the media

Games like this

Games released in the last 12 months with similar themes, genres, categories, and wishlist tier.

S.E.M.I. – Side Effects May Include... - Player count and game stats

Peak Concurrent Players

PC System Requirements

Price History

Player Reviews

Player Reviews by Day

Official Announcements

News from the media

Games like this

Project: Mist

Frog Sqwad 🐸

Sujefa

The Horde Wants You Dead

Boat Together