Incident Number Eight is a hardcore third-person 3D platformer. You are Number Eight, a volunteer with amnesia. To remember what led to the disaster, you relive the recordings from your helmet. Each video is a high-speed sprint through the corners of a pocket universe created for secret experiments.

The protagonist awakens in a medical capsule, wearing only underwear and no spacesuit. Her consciousness is a blank slate. No name, no understanding of how she ended up here. As soon as she leaves the medical capsule, the doors open and she is greeted by a robot assistant who identifies her only as "Number Eight".

The robot informs her that her helmet awaits in the next room, connected to computers. The recordings on it have survived, and they can be used to reconstruct her memory.

Each individual recording is a level, a deadly obstacle course of spikes, lasers, and hostile drones.

On the way to her goal, she will have to overcome obstacles using gravity, portals, teleports, dashes, and other abilities, all while managing her oxygen and spacesuit's energy.